perhaps a few of you know that the DNA polymerase and 'a replication tool that can control the base when engaged (and replace if necessary) before proceeding to the next.
for this reason, its accuracy and 'very high, an error on the order of 10 ^ 7.
though, so the errors made by DNA polymerase are very rare, a further correction system, remedy 99% of them, increasing the accuracy of replication to one in 10 ^ 9.
three different proteins contribute to this: a nuclease (which eliminates the wrong basis), a corrective polymerase (which joins the new foundation as a primer using the strand of the adjacent Okazaki), and finally a ligase (which is responsible to pay the 'sugar-phosphate backbone).
is obvious that these proteins, not being anchored to the DNA strand along with the replication complex, should identify and work only on newly synthesized strand: a correction of the wrong strand (the one that acts as a mold), in fact lead to a consolidation of the error, with potentially serious consequences for the cell and the body.
as they recognize the filament is not exactly 'not entirely clear, but it is assumed that this' may depend on the number of interruptions that the latter nell'ossatura sugar-phosphate, not settled by the ligase, which would serve as an indicator.
and nothing.
so '.
add that I will ask the Millionaire ...
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